Acute Ocular Pain
What Is Acute Ocular (Corneal) Pain?
The cornea has an incredibly high density of sensory nerves, the majority of which are pain nerves. That translates into a density of pain-sensing nerves between 300 and 600 times higher than the density of pain sensors on your skin.1 The most common cause of acute ocular pain is ocular trauma that scratches the corneal surface, including accidental trauma or during cataract or refractive surgery.1,2
Current Treatment Options
Our NVK032 Program
Vyluma is developing NVK032, a non-NSAID, non-steroid, non-anesthetic topical eye drop for the treatment of acute corneal pain, such as pain experienced after a traumatic corneal abrasion, eye surgery, or other eye injury.
- Rastgarian A, Abedi H, Radmehr M, Damshenas M, Heydari E. Effects of eugenol on acute corneal pain of male rats. Pharmacophore. 2017;8(1):73-77.
- Belmonte C, Nichols JJ, Cox SM, Brock JA, Begley CG, Bereiter DA, et al. TFOS DEWS II pain and sensation report. Ocul Surf. 2017;15(3):404-437.
- Cataract in the adult eye PPP – 2016. American Academy of Ophthalmology. https://www.aao.org/preferred-practice-pattern/cataract-in-adult-eye-ppp-2016. Published October 2016. Accessed March 18, 2021.
- Kiernan DF, Mieler WF. The use of intraocular corticosteroids. Expert Opin Pharmacother. 2009;10(15):2511-2525.